Welcome, not familiar with the area but I'd suggest trying creek mouths close to lake, fish love areas like that. Looking to target a specific species? Maybe we can help narrowing down where to fish if you let us know what you're trying to catch
Grindstone Creek is open right now from the Hamilton Harbour, all the way to Hwy #2 (Plains Road). Spencer Creek is also open from Hwy 102 (Cootes Drive) to Lake Ontario.
Always double check to make sure that you're fishing in season species/areas. troutddicted is right about fishing creek mouths or harbour mouths - lots of staging fish this time of the year.
I live in Hamilton myself and know quite a bit of water around the area for a few different species. Give me a PM with more info and maybe we can figure something out